Dihydropyridines: a new class of angiotensin II antagonists

Ronald Thure Wester,Christian J. Mularski,George T. Magnus-Ayritey,Paul Da Silva Jardine,Janet A. LaFlamme,Helen Berke,Donald L. Bussolotti,Albert L. Rauch,Karen W. Hoover,Christine A. Kennedy,Michael Burkard,Michael L. Mangiapane,Charles E. Aldinger,Kelvin Cooper,Philip A. Carpino

Dihydropyridines: a new class of angiotensin II antagonists

1994

Ronald Thure Wester
Christian J. Mularski
George T. Magnus-Ayritey
Paul Da Silva Jardine
Janet A. LaFlamme
Helen Berke
Donald L. Bussolotti
Albert L. Rauch
Karen W. Hoover
Christine A. Kennedy
Michael Burkard
Michael L. Mangiapane
Charles E. Aldinger
Kelvin Cooper
Philip A. Carpino

Abstract The syntheses and biological activities of dihydropyridine angiotensin II (AII) antagonists are described. Compounds such as 12 are examples of a new, structurally distinct class of AT(in1-selective agents.

Keywords:

Combinatorial chemistry
Angiotensin II
Chemical synthesis
Biological activity
Stereochemistry
Dihydropyridine
Chemistry
Pharmacology

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