A novel 5-fluorouracile anticancer drug sensor based on ZnFe2O4 magnetic nanoparticles ionic liquids carbon paste electrode

Abstract A carbon paste electrode modified in situ with ZnFe 2 O 4 magnetic nanoparticles (ZnFe 2 O 4 /MNPs) and 1,3-dipropylimidazolium bromide ionic liquid was developed for the determination of 5-fluorouracile (5-FU) in drug samples. The electrochemical behavior of 5-FU was investigated employing linear sweep voltammetry (LSV), square wave voltammety (SWV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS). ZnFe 2 O 4 /MNPs synthesized by co-precipitation method and characterized with different methods such as energy dispersive X-ray analysis (EDAX), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM). After optimization of experimental conditions employing the novel sensor at pH 7.0, the electro-oxidation peak currents for 5-FU was found to vary linearly with its concentrations in the range of 0.1–1400 μM using SWV method. The ZnFe 2 O 4 /MNPs ionic liquids carbon paste electrode (ZnFe 2 O 4 /MNPs/IL/CPE) showed several advantages, such as a high sensitivity in trace analysis, good detection limits and excellent reproducibility. Furthermore, the ZnFe 2 O 4 /MNPs/IL/CPE was successfully applied for the analysis of 5-FU in pharmaceutical and urine samples.