Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

Hannah M. Jones,Iain Gardner,Wendy Collard,Phil Stanley,Penny Oxley,Natilie Hosea,David R. Plowchalk,Steve S. Gernhardt,Jing Lin,Maurice Dickins,S. Ravi Rahavendran,Barry C. Jones,Kenny J. Watson,Henry Pertinez,Vikas Kumar,Susan Cole

Simulation of Human Intravenous and Oral Pharmacokinetics of 21 Diverse Compounds Using Physiologically Based Pharmacokinetic Modelling

2011

Hannah M. Jones
Iain Gardner
Wendy Collard
Phil Stanley
Penny Oxley
Natilie Hosea
David R. Plowchalk
Steve S. Gernhardt
Jing Lin
Maurice Dickins
S. Ravi Rahavendran
Barry C. Jones
Kenny J. Watson
Henry Pertinez
Vikas Kumar
Susan Cole

Background: The importance of predicting human pharmacokinetics during compound selection has been recognized in the pharmaceutical industry. To this end there are many different approaches that are applied.

Keywords:

Anesthesia
Oral administration
Physiologically based pharmacokinetic modelling
Pharmacology
Pharmacokinetics
Medicine
pharmacology toxicology
area under curve
Metabolic clearance rate

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