[Antithrombogenic activity of blood vessel walls in the pathogenesis of metastasis in tumor-bearing animals].

The purpose of this work was to examine the relationship between the antiaggregatory activity of the vascular wall and the metastatic spread of experimental tumors. Rats with the tumor "Myosarcoma-1" displayed, on the average, a 30% reduction in the antiaggregatory activity of the aortic wall. Three-week of the animals with a combination of the drugs dipyridamole (0.84 mg/kg per os), phytin (14 mg/kg per os), glutamic acid (28 mg/kg per os) restored the antiaggregatory properties of the vascular wall virtually up to the control values. The similar result was observed with cordarone (60 mg/kg intraperitoneally): the antiaggregatory properties of the vascular wall increased on the average by 50%. The metastatic spread of tumor cells in mice with Lewis carcinoma of the lung decreased on the average twice while treating them with these agents. The findings point to the fact that drug correction of the antiaggregatory activity of the vascular wall reduces the rate of metastatic spread.