ORAL LEIOMYOMA: UNUSUAL CLINICAL MANIFESTATION OF A RARE LESION

Oral leiomyoma is a benign smooth muscle neoplasm of rare incidence, described as an asymptomatic nodule. We report a case of solid leiomyoma with a distinctive clinical manifestation in the anterior tongue. A 46-year-old woman complained of pain in her tongue with impairment of chewing and speaking for 2 months. Clinically, she presented with a depression covered by a pink-colored smooth mucosa, also surrounded by whitish prominent borders. The lesion was firm measuring 7 mm. Incisional biopsy was performed. Histologic examination revealed a noncapsulated proliferation of spindle cells with pale, eosinophilic, and vacuolated cytoplasm containing elongated cigar-shaped nuclei, which were organized in sweeping fascicles intermingled with muscle tissue, blood vessels, and inflammatory infiltrate. No evidence of cellular atypia was found. Tumor cells were strongly marked with muscle-specific actin antibody, but negative for S-100 protein. The final diagnosis was leiomyoma. After 3 months of complete excision, no pain or signs of recurrence were noted.