Percutaneous ethanol injection therapy: a surgery-sparing treatment for primary hyperparathyroidism.
2008
Summary
Objective To describe our 3-year experience in the long-term efficacy and safety of percutaneous ethanol injection therapy (PEIT), as an alternative to surgery for the management of patients with primary hyperparathyroidism (p-HPT).
Design Prospective study with a mean follow-up of 19·6 ± 10·6 months.
Patients Our study population included 19 consecutive high risk patients with p-HPT, who met the criteria for surgery.
Measurements Under ultrasonic guidance, ethanol (95%) was injected into parathyroid glands with a volume of ≥ 0·15 cm3. With the aim of normalizing intact parathormone (iPTH) values, repeated ethanol injections were carried out, in an interval of 2 weeks, until normalization of iPTH was reached or until no residual blood supply was detected by ultrasound in the gland. Biochemical parameters were monitored throughout the study.
Results At 6-month follow-up, normalization of iPTH levels (10–65 ng/l) was achieved in 11 (58%) patients (responders). Of the eight remaining patients (nonresponders), six patients had reduced (but not normalized) iPTH levels and two patients required parathyroid surgery. Seventeen (11 responders and 6 nonresponders) of the 19 patients (89·5%) became normocalcaemic (serum Ca ≤ 2·57 mmol/l) and remained so for a mean follow-up of 21 months (8–39 months). The odds ratio (P 200 ng/l. The only complication was a transient dysphonia noticed in three patients.
Conclusions PEIT is a safe and effective nonsurgical treatment for patients with p-HPT, who are unsuitable for surgical intervention.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
33
References
20
Citations
NaN
KQI