Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

Tip60 is a transcriptional coregulator that has an important role in differentiation. Here, Gao et al. demonstrate that the deubiquitination of Tip60 by USP7, a dominant deubiquitinating enzyme, is a key mechanism in early adipogenesis regulation.