PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

Lubin Jiang,Jianbing Mu,Qingfeng Zhang,Ting Ni,Prakash Srinivasan,Kempaiah Rayavara,Wenjing Yang,Louise Turner,Thomas Lavstsen,Thor G. Theander,Weiqun Peng,Guiying Wei,Qingqing Jing,Yoshiyuki Wakabayashi,Abhisheka Bansal,Yan Luo,José M. C. Ribeiro,Artur Scherf,L. Aravind,Jun Zhu,Keji Zhao,Louis H. Miller

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

2013

The malaria parasite Plasmodium falciparum escapes immune detection by expressing one of 60 antigenically distinct var genes at any one time during the course of infection: here it is shown that the P. falciparum protein PfSETvs has a key role in var gene silencing through the trimethylation of histone H3K36.

Keywords:

Methylation
Transcription factor
Gene silencing
Histone
Plasmodium falciparum
Gene
TBX1
Virulence
Biology
Genetics
Gene expression
Histone H3
Transcription (biology)

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