Macrophage migration inhibitory factor promoter polymorphisms (−794CATT5–7) as potential biomarker for early-stage cervical cancer

Aim The objective was to investigate the correlation between macrophage migration inhibitory factor (MIF) promoter polymorphisms (−794CATT5–7) and early-stage cervical cancer (ESCC) and to identify a potential biomarker for ESCC. Methods A hospital-based case–control study was performed. The case group contained 250 patients with histologically confirmed ESCC. The control group included 147 healthy women. Polymerase chain reaction-single strand conformation polymorphism was used to genotype polymorphisms of MIF promoter -794CATT5–7. Enzyme-linked immunosorbent assay was applied to detect serum concentration of MIF. Results The genotype distribution and allele frequency of MIF-794CATT in the ESCC group were significantly different from those in the control group (P   0.05). Conclusion MIF promoter polymorphisms (−794CATT) were correlated with ESCC; and 7-CATT might play a role in ESCC. It could be a potential biomarker for ESCC.