The Compound Packaged in Virions is the Key to Trigger Host Glycolysis Machinery for Virus Life Cycle in Cytoplasm

WSSV can package some compounds during the infection, among which palmitic amide significantly promoted virus infection. Palmitic amide packaged in virions was released to upregulate HIF-1, leading to the enhancement of glycolysis. Palmitic amide directly bound to triosephosphate isomerase (TPI), an important enzyme in the glycolysis pathway, enhanced the activity of TPI. The enhanced TPI enzyme activity could upregulate the expression of HIF-1 and promote virus infection.