The prebiotic lactosucrose modulates gut metabolites and microbiota in intestinal inflammatory rats

The effect of lactosucrose on the short chain fatty acid (SCFA) content, the intestinal flora, the acidity, and the amino nitrogen (NH3-N) content of the intestine in inflammatory bowel disease (IBD) rats was investigated. Dietary lactosucose supplementation increased amounts of beneficial bacteria and diminished amounts of pathogenic bacteria. Lactosucrose decreased the NH3-N content in cecal and colonic digesta, compared to inflammatory rats. Lactosucrose increased the acidity in the intestinal lumen, and the acetic acid, propionic acid, and butyric acid contents in cecal and colonic digesta, compared to inflammatory rats. The butyrate content in the lactosucrose group was higher than for the inflammatory, sulfasalazine, and normal groups. Lactosucrose promoted beneficial intestinal health and prevented intestinal inflammation.