The Use of an Automated Quantitative Polymerase Chain Reaction (Xpert MTB/RIF) to Predict the Sputum Smear Status of Tuberculosis Patients
2012
(See the Editorial Commentary by Fennelly, on pages 389–91.)
Xpert MTB/RIF–generated cycle-threshold (CT) values have poor clinical utility as a rule-in test for smear positivity (cut-point ≤20.2; sensitivity 32.3%, specificity 97.1%) but moderately good rule-out value (cut-point >31.8; negative predictive value 80.0%). Thus, 20% of individuals with CT values >31.8 were erroneously ruled out as smear-negative. This group had a significantly lower sputum bacillary load relative to correctly classified smear-positive patients (CT ≤ 31.8; P < .001). These data inform on public health and contact tracing strategies.
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