Executive functions in aging adult survivors of childhood leukemia.

9011 Background: Survivors of childhood ALL are at risk for deficits in basic cognitive skills (e.g. attention, processing speed and working memory), typically beginning within five years of diagnosis and associated with cranial radiation therapy (CRT). The degree of impairment in very long-term survivors is unknown. Methods: We evaluated complex neurocognitive functions (i.e. executive functions [EF]), in 285 adult survivors of childhood ALL (mean [range] of current age = 35.0 yrs [20.4 – 49.9], age at diagnosis = 6.0 yrs [0.2 – 18.8], and time since diagnosis = 28.9 yrs [12.0 – 45.3]. Survivors completed a comprehensive neuropsychological evaluation. Age-adjusted standard scores were calculated using national norms, with clinical impairment defined as scores ≤ 10th percentile. Analysis of variance and regression was used to examine associations between executive functions and CRT, sex, and age at diagnosis, as well as educational and vocational outcomes. Results: 72.6% of survivors demonstrated impairme...