Experimental animal studies on the significance of endogenous prostaglandins in maintaining the integrity of the stomach mucosa after truncal vagotomy

: The changes of the transmucosal potential difference, the ionic flow, and the prostaglandin content were investigated after pylorus ligation, truncus vagotomy, and pylorus ligation with truncus vagotomy in Shay rats. A damage of the mucosa appeared already 10 hours after the pylorus ligation. This was presented in a clear decrease of the transmucosal potential difference and a change of the ionic flow. These damages could be prevented by simultaneous truncus vagotomy. A decrease of the PGF2 alpha content in the gastric antrum and rumen as well as an increase of the TXB2 in the gastric rumen were observed after additional pylorus ligation. The 6-keto-PGF1 alpha and the TXB2 content in the gastric antrum and rumen increased after truncus vagotomy. TXB2 in the rumen, 6-keto-PGF1 alpha in the rumen and antrum, as well as PGF2 alpha in the antrum ascended after pylorus ligation with simultaneous truncus vagotomy. The truncus vagotomy shows additionally a protective effect for the mucosa and influenced synergistically the content in prostaglandin after these results besides the notorious importance for the secretion of H+ion and bicarbonate.