Effect of lornoxicam on postoperative inflammatory reaction in patients undergoing laparoscopic appendectomy

Objective To investigate the effects of lornoxicam on postoperative inflammatory reaction in patients undergoing laparoscopic appendectomy.Methods Sixty ASA Ⅰ - Ⅱ patients undergoing laparoscopic appendectomy were assigned to study group and control group ( 24 for each ).The study group received intravenous loronoxicam of 8 mg diluted with normal saline of 2ml before anesthesia,and the control group received the same volume of normal saline.All the patients were anesthetized with combined spinal and epidural blockage and tranquilized with pethedine,droperidol,and diazepam.Peripheral vein blood were extracted one hour before surgery and one day after operation to measure leukocyte count; the concentration of C reaction protein ( CRP ) was detected.Results Leukocyte count and CRP concentration were markedly decreased ond day after surgery in both groups ( P＜ 0.05 ).Leukocyte count and CRP concentration were significantly lower in the study group than in the control groupt[( 5.4 + 3.7 ) vs.( 7.6 +3.2) and (6.4 ± 3.7) vs.(9.6 ± 4.1 ),P＜ 0.05 for both comparisons].Conclusions Intravenous lornoxicam before anesthesia can suppress inflammatory reaction during early postoperative stage in patients undergoing laparoscopic appendectomy. Key words: Lomoxicam;  Laparoscopy;  Appendectomy;  Postoperation;  Inflammatory reaction