S49 THE EFFECTIVENESS OF SINGLE DOSE FOSFOMYCIN AS ANTIMICROBIAL PROPHYLAXIS FOR PATIENTS UNDERGOING TRANSRECTAL ULTRASOUND-GUIDED BIOPSY OF THE PROSTATE

Objectives: It was the aim of this study to evaluate the efficacy of single-dose fosfomycin prophylaxis as an alternative to fluoroquinolone-based prophylaxis in transrectal ultrasound-guided biopsy of the prostate (TRUSBP). Methods: We evaluated the records of 620 patients who had undergone TRUSBP from January 2010 to July 2011. Patients received a single dose of 3 g oral fosfomycin or a single dose of 500 mg oral levofloxacin or 500 mg oral ciprofloxacin twice daily administered for 5 days starting 1 day before the prophylaxis procedure. We reviewed all febrile and afebrile urinary tract infections (UTIs) within 1 month after TRUSBP. Results: Of the 620 patients, 19 (3.0%) developed febrile UTI and 51 (8.2%) developed afebrile UTI after biopsy. Of the 19 patients with febrile UTI, 1/19 (5.2%) received fosfomycin, 4/19 (21%) received levofloxacin and 14/19 (73.6%) received ciprofloxacin for prophylaxis. Of the 51 patients with afebrile UTI, 4/51 (7.8%) received fosfomycin, 8/51 (15.6%) received levofloxacin and 39/51 (76.4%) received ciprofloxacin for prophylaxis. There were a total of 10 fluoroquinolone-resisReceived: May 14, 2012 Accepted after revision: July 27, 2012 Published online: September 22, 2012 Internationalis Urologia Dr. Şakir Ongun Dokuz Eylul University School of Medicine Department of Urology Izmir (Turkey) E-Mail sakirongun @ hotmail.com © 2012 S. Karger AG, Basel 0042–1138/12/0894–0439$38.00/0 Accessible online at: www.karger.com/uin D ow nl oa de d by : 20 7. 46 .1 3. 17 9 7/ 6/ 20 16 7 :0 2: 40 A M