Quality of compensation and well-being of patients with primary hypothyroidism and obesity

Aim. The aim of the study was to compare quality of hypothyroidism compensation and well-being of patients with hypothyroidism with normal weight, overweight and obesity. Methods. 306 patients with hypothyroidism on replacement therapy with L-T4 were included; of those 218 patients with compensated hypothyroidism. All patients were divided into groups depending on their body mass index: with normal body weight, overweight, obesity I and obesity II - III degree. We calculated the ideal body weight (IdBW) by Devine formula. Evaluation at baseline included: height, weight, BMI, quality of life (SF-36), TSQ, TSH, freeT3 (fT3), freeT4 (fT4) levels. Results There were no difference in the quality of compensation between groups of normal-weight, overweight and obese patients (p > 0,05). L-T4 dose in patients with obesity and overweight was significantly higher compared to normal-weight patients (p 0,05). Conclusions The compensation of hypothyroidism in patients with overweight/obesity is not worse than that of normal-weight patients. The achievement of euthyroidism requires less L-T4 dose per 1 kg of the actual weight and significantly higher dose for 1 kg of ideal weight in obesity/overweight patients.