Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation

Maciej Kujawski,Mark Sherman,Susanta K Hui,Darren Zuro,Wen-Hui Lee,Paul J. Yazaki,Anakim Sherman,Barbara Szpikowska,Junie Chea,Desiree Lasiewski,Kofi Poku,Harry Li,David Colcher,Jeffrey Y.C. Wong,John E. Shively

Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiation

2020

Maciej Kujawski
Mark Sherman
Susanta K Hui
Darren Zuro
Wen-Hui Lee
Paul J. Yazaki
Anakim Sherman
Barbara Szpikowska
Junie Chea
Desiree Lasiewski
Kofi Poku
Harry Li
David Colcher
Jeffrey Y.C. Wong
John E. Shively

ABSTRACTWhile anti-CEA antibodies have no direct effect on CEA-positive tumors, they can be used to direct potent anti-tumor effects as an antibody-IL-2 fusion protein (immunocytokine, ICK), and at...

Keywords:

Medicine
Cancer research
Fusion protein
Antibody
Breast cancer
tumor therapy
stereotactic radiation

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