Evaluation of the frequency of gonadotroph adenoma with immunohistochemistry among surgical specimens of pituitary adenoma in Isfahan, Iran

Introduction: Gonadotroph adenomas are a type of pituitary adenomas. It is now clear that these adenomas are relatively more frequent than previously thought. Objectives: The aim of the present study is to investigate the prevalence of gonadotropin pituitary adenomas. Patients and Methods: Specimens of surgically resected of 188 patients with pituitary adenomas were collected. In this study chromogranin A was used for immunostaining and identifying gonadotroph adenomas. Results: Immunostaining turned out to be positive in 93 specimens out of 188. Data analysis indicated a correlation between gender and gonadotropin adenomas prevalence (P = 0.041), since of 93 positive specimens, 57.6% were males. Conclusion: Gonadotroph cells are commonly seen in pituitary adenoma patients. Men are at higher risk of developing this type of tumor.