pH Control in Aqueous Processes: N-4-Methylsulfonylphenylguanidine
2007
The kinetics and mechanism of the synthesis of the sulfonylguanidine 2 by reaction of the corresponding aniline, 1, with cyanamide have been investigated in aqueous acid solution. The reaction is acid-catalysed, but at low pH, where substantial protonation of 1 occurs, the dominant reaction occurring is a competing hydrolysis of cyanamide to urea. It is shown that reactions run under pH control in the region of pH 2 achieve close to maximum selectivity with respect to the desired guanidine formation, whilst still occurring at a practical rate.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
7
References
4
Citations
NaN
KQI