Antinociceptive activity evaluation of an Indonesian herbal product Sekalor 33A in Swiss albino mice.

The antinociceptive activity of an Indonesian herbal product named Ulu Hati was evaluated in Swiss albino mice in acetic acid-induced abdominal pain model. The product, when administered to mice at doses of 25, 50, 100 and 200 mg per kg body weight, reduced the number of acetic acid-induced gastric constrictions by 10.0, 23.4, 46.6, and 50.0%, respectively. The results were statistically significant at the two higher doses of the product when compared to control animals. In comparison, a standard antinociceptive drug, aspirin, when administered at doses of 200 and 400 mg per kg body weight, reduced the number of gastric constrictions in mice, respectively, by 33.4 and 66.6%. The results suggest that the herbal product is comparable to aspirin in alleviation of pain and validates the use of this product for colic pain occurring during gastritis.