Effects of adenosine cyclophosphate on myocardiac enzymes in patients undergoing orthotopic liver transplantation

Objective To study the effect of adenosine cyclophosphate (cAMP) on myocardiac enzymes in patients undergoing orthotopic liver transplantation(OLT),and to search for a feasible method of preventing and reducing myocardiac injury.Methods Forty patients undergoing OLT were randomly divided into two groups with 20 cases each: control group and cAMP group.The two groups were pumped intravenously with equal volume of saline and cAMP 2.0 mg/(kg·h) by micropump separately from the time of dissecting the second porta hepartis to 2 hours after the beginning of neohepatic phase.Results The CPK and CKMB levels in the cAMP group were significantly lower than those in the control group.Conclusion cAMP can effectively reduce myocardiac injury to some extent