Three new phenolic glycosides from the whole plant of Aconitum tanguticum (Maxim.) Stapf

Abstract Three new phenolic glycosides 2-(3-O- β - d -glucopyranosyl-4-hydroxyphenyl) ethanol 1- O - β - d -glucopyranoside ( 1 ), 2-(4-O- β - d -fructopyranosylphenyl) ethanol 1- O - β - d -galactopyranoside ( 2 ) and 3-methoxy-4-O- β - d -allopyranosyl acetophenone ( 3 ), along with nine known compounds ( 4–12 ), were isolated from the ethanol extract of the whole plant of Aconitum tanguticum (Maxim.) Stapf. Their structures were elucidated by analysis of spectroscopic data including 1D-, 2D-NMR and HRESIMS, and the reported literature data comparison. All the compounds were evaluated for their potential anti-inflammatory effects by the inhibition of TNF-α production on LPS-stimulated RAW264.7 macrophages. Compounds 1 , 3 , 5 and 7 – 9 showed certain inhibition activity and their IC 50 values were 38.18, 27.64, 3.25, 84.45, 12.76 and 18.44 μg/mL, respectively.