Synthesis and Antiviral Evaluation of α-D-2′-3′-Didehydro-2′,3′-dideoxy-3′-C-hydroxymethyl Nucleosides.

Abstract We have identified a selective S N 2′ reaction triggered by iodide ion that leads to the ring-opening of 2,2′-anhydro-α-nucleosides. By applying the method, we have synthesized α- d -2′,3′-didehydro-2′,3′-dideoxy-3′- C -hydroxymethyl nucleosides, designed as potential antiviral agents.