MORPHOFUNCTIONAL FEATURE IN EXPERIMENTAL MYOCARDIAL DAMAGE HEART ON THE BACKGROUND OF DIABETES AND CYTOPROTECTOR

N.P. OGAREV MORDOVIAN STATE UNIVERSITY , 430000, Saransk, Bolshevist st, 68 Abstract. The article highlights the experiments on white mice and purebred cats, which simulated insulin-dependent diabetes by intra-abdominal injection of water solution streptozotocin in the dose of 15 mg/kg, which destroys β-cells of the pancreas within 14 days and leads to increased blood glucose animals by 70-80% compared with intact animals. In the experiment, the authors studied the de- rivative of L-glutamic acid deanol aceglumate at the preventive intragastric introduction, which showed the presence of cardioprotec- tive effect in the animals with ischemic, stress and metabolic damage to the heart. This was expressed in the reduction of deaths mice with diabetes subjected to 25% immobilization stress in the period of 28 days, and in improving the adaptation of animals to prolonged immobilization. The data obtained are confirmed by the absence of reducing the weight of the animals during the experiment, an ob- stacle to development of relative and absolute myocardial hypertrophy, lack of pronouced destructive processes in the contractile car- diomyocytes left stomach animals, increased life expectancy, animals when modeling adrenaline micronecrosis in mice with diabetes, improving gas and acid-base composition of venous blood outflow from ischemia heart cats with acute ischemia and diabetes.