Antibiotic Exposure in the First Two Years of Life and Development of Asthma and Other Allergic Diseases by 7.5 yr: A Dose-Dependent Relationship.

L Hoskin-Parr, A Teyhan, A Blocker, AJ Henderson. Pediatr Allergy Immunol. 2013;24(8):762–771 The goal of this study was to investigate the associations of antibiotic use in the first 2 years of life with the development of asthma, eczema, and hay fever by age 7.5 years in a longitudinal birth cohort. Subjects were 4952 children from ALSPAC (Avon Longitudinal Study of Parents and Children), a population-based cohort that recruited 14 541 expectant mothers with due dates between April 1, 1991, and December 31, 1992, in Avon, United Kingdom. Child antibiotic use and asthma, eczema, and hay fever symptoms were maternally reported through questionnaires collected annually when subjects were ≥6 months of age. In 3 questionnaires …