Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

Mariya Misheva,Konstantinos Kotzamanis,Luke C. Davies,Victoria J. Tyrrell,Patricia Rodrigues,Gloria Benavides,Hinz Christine,Robert C. Murphy,Paul D. Kennedy,Philip R. Taylor,Marcela Rosas,Simon Jones,Sumukh Deshpande,Robert Andrews,Magdalena Czubala,Mark Gurney,Maceler Aldrovandi,Sven W. Meckelmann,Peter Ghazal,Victor M. Darley Usmar,Daniel White,Valerie B. ODonnell

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

2020

Oxylipins are potent mediators requiring strict control. How they are removed en masse during infection/inflammation is unknown. Herein, lipopolysaccharide (LPS) dynamically increased their mitochondrial b-oxidation, impacting leukocyte bioactivity. Genetic/pharmacological targeting of CPT1 showed

Keywords:

Oxylipin metabolism
Inflammation
Chemistry
Beta oxidation
Lipopolysaccharide
Microbiology

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations