The changes of platelet aggregation in diabetic patients treated with rapid control of blood glucose or surgical treatment. Correlation with diabetic retinopathy.

The prevention of diabetic microangiopathy, especially retinopathy, is the last goal of treatment of diabetic patients. Retinopathy is found to progress following rapid control of blood glucose or surgical treatment. To investigate the deterioration of retinopathy, the changes of platelet aggregation induced by ADP, collagen, PAF and epinephrine, of the arachidonate cascade (TXB2 and 6-keto PGF1α), and of blood viscosity were measured during and after surgical treatment or after rapid control of blood glucose. Blood was obtained from 22 diabetics with rapid control of blood glucose and from 11 diabetics undergoing surgical treatment.Platelet aggregation induced by all aggregators was increased after rapid control of blood glucose and after surgical treatment, but decreased during operation. When platelet aggregation before surgical treatment was exaggerated, retinopathy tended to be worsened after surgical treatment. Concerning the arachidonate cascade, both TXB2 and 6-keto PGF1α were increased and the TX/6-keto PGF1α ratio was decreased during operation.