The squalestatins: Potent inhibitors of squalene synthase, 3-hydroxymethyl derivatives.
1994
A series of 3-hydroxymethyl derivatives of squalestatin 1 was prepared as inhibitors of squalene synthase. Potent in vitro inhibitory activity is retained in those analogues which possess C-6 and C-1 substituents analogous to those found in 1.
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