Penetration of fleroxacin into body tissues and fluids.

Concentrations of fleroxacin in human body fluids and tissues were studied to obtain information about the efficacy of the drug at the site of infection and the ratio of fleroxacin concentrations in tissue or fluid versus those in plasma as a measure of the extent of penetration. Samples of body fluids and tissues were obtained at various intervals after oral administration, and fleroxacin concentrations were determined by high-performance liquid chromatography. After administration of the standard dose of 400 mg once daily, the maximal plasma concentrations were 5-7 mg/L at steady-state and the minimal concentrations were approximately 1 mg/L at the end of the dosing interval