Genetic polymorphism in RANK is associated with mandibular size

ABSTRACTObjective: The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans.Design: DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM–A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism.Setting: School of Dentistry of Ribeirao Preto, University of Sao Paulo.Participants: A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study.Results: The polymorphism in RANK was associated with a higher Go-Pg measurement (p = .039). In the multivariat...