New Frontiers in Solid Organ Transplantation from Donors with Human Immunodeficiency Virus, Hepatitis C Virus Infection, and Multidrug Resistant Organisms

Despite the advances that have been made in the field of solid organ transplantation (SOT), organ shortage remains a persistent problem and continues to worsen. In addition, the donor pool has been changing with the increase in drug overdose deaths each year with the ongoing opioid epidemic More donors are meeting the 2013 U.S. Public Health Service criteria for increased risk donors, or donors who are at higher risk for transmission of Human Immunodeficiency Virus (HIV), Hepatitis C virus (HCV), and other multidrug resistant organisms (MDROs). While previously not considered due to concerns about recipient and allograft outcomes, organs from donors with HIV, HCV and MDROs are now being utilized for transplant. This has the potential to expand the donor pool and research needs to continue evaluating optimal management of these donors to ensure the best outcomes. This paper reviews the current literature