Influence of vinyl chloride monomer (VCM) and As2O3 on rat liver cell proliferation after partial hepatectomy

Male Wistar rats (240–320 g b. wt.) were partially (2/3) hepatectomised and immediately thereafter exposed to inhalation over 28 h of vinyl chloride monomer (VCM) at concentrations of 0, 50, 125, and 500 ppm. An investigation was also performed in which, following partial hepatectomy, rats of 130–150 g b. wt. were infused by the caudal vein over 28 h with As2O3 (AT) at concentrations of 0, 1, 2, and 10 mg/ml. The total volume of the infusion was 16.8 ml.