Syk inhibitors Imidazopyrazine

At least one chemical entity chosen from compounds of Formula (I): ** ** Formula and pharmaceutically acceptable salts thereof, wherein R1 is selected from (1-hydroxycyclobutyl) phenyl, (1,1,1-trifluoro -2-hydroxypropane-2-yl) phenyl, (2,2,2-trifluoro-1- hydroxyethyl) phenyl, (1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl) phenyl (2-hydroxy-2-methylpropoxy) -3-methoxyphenyl, (2- hydroxyethyl) (methyl) amino) -3-methoxyphenyl, (2-methoxyethyl) (methyl) amino) -3-methoxyphenyl, (1-hydroxyethyl) phenyl, 3,4- dimethoxyphenyl, 3-methoxyphenyl, 4-ethoxy-3-methoxyphenyl, 4-hydroxymethyl-3-methoxyphenyl, 3-hydroxymethyl-4-methoxyphenyl, 2-fluoro-4-methoxyphenyl, 4- (dimethylamino) propoxy -3-methoxyphenyl, 4-hydroxypropoxy-3-methoxyphenyl, 4- (2-hydroxy-1,1- dimethylethyl) phenyl, 4- (1-hydroxy-1-methylethyl) phenyl, 4-methoxy-3- (pyrrolidin- 1-yl) phenyl, 3-methoxy-4- (pyrrolidin-1-yl) phenyl, 3- methoxy-4- (propan-2-yloxy) phenyl, 3-methoxy-4- (morpholin-4-yl) phenyl , 4- (pyrrolidin-1-yl) phenyl, 4- (3-hydroxypyrrolidinyl) phenyl, 4- (4-hydroxypiperid ynyl) -3-methoxyphenyl, 4- (3-hidroxiacetidinil) -3-methoxyphenyl, 4- (3-hydroxypyrrolidinyl) -3-methoxyphenyl, 4- (2-methoxypropan-2-yl) phenyl, 4- (4-ethylpiperazin -1-yl) -3-methoxyphenyl, 4- (4-ethyl-piperazin-1-yl) phenyl, 4- (3-hydroxy-3- methylpiperidinyl) phenyl, 3-hydroxymethylphenyl, 3,4-dihydro-2H-benzo [ b] [1,4] oxazin-6-yl, 4-methyl-3,4-dihydro-2H-benzo [b] [1,4] oxazin-6-yl, 2,3,4,5-tetrahydrobenzo [b] [1,4] oxazepine-7-yl, 5-methyl-2,3,4,5-tetrahydrobenzo [b] [1,4] oxazepine-7-yl, 2,3-dihydro-1H-indol-2- one-6-yl and 2,3-dihydro-1H-indol-yl 2-one-5-; R2 is selected from 2-fluoropyridin-4-yl, 5-methylpyridin-3-yl, 5-chloropyridin-3-yl and 2-aminopyridin-5-yl; R3 is chosen from hydrogen, halo and C1-C4 alkyl; R4 is chosen from hydrogen and C1-C4 alkyl; and R5 is hydrogen.