Metabolism of a Bioorthogonal PET Tracer Candidate [19F/18F]SiFA-Tetrazine in Mouse Liver Microsomes: Biotransformation Pathways and Defluorination Investigated by UHPLC-HRMS.

Sofia Otaru,Hanna Niemikoski,Mirkka Sarparanta,Anu J. Airaksinen

Metabolism of a Bioorthogonal PET Tracer Candidate [19F/18F]SiFA-Tetrazine in Mouse Liver Microsomes: Biotransformation Pathways and Defluorination Investigated by UHPLC-HRMS.

2020

Sofia Otaru
Hanna Niemikoski
Mirkka Sarparanta
Anu J. Airaksinen

Organofluorosilicon based 18F-radiolabeling is an efficient method for incorporating fluorine-18 into 18F-radiopharmaceuticals for positron emission tomography (PET) by 19F/18F isotopic exchange (I...

Keywords:

Biochemistry
Chemistry
Biotransformation
liver microsomes
Bioorthogonal chemistry
Positron emission tomography
Metabolism
pet tracer
uhplc hrms
Tetrazine

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