Does rilmenidine act in vivo on central α2-adrenoceptors modulating noradrenaline release ?
1992
Abstract Noradrenaline release evoked by electrical stimulation was recorded in the rat hypothalamus by in vivo electrochemistry. Rilmenidine (0.3–10 mg kg −1 i.v.) did not diminish this evoked release while clonidine induced a dose-dependent decrease. These results further suggest that the antihypertensive action of rilmenidine is not mediated by central α 2 -adrenoceptors and might explain why, unlike clonidine, rilmenidine does not have sedative effects.
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