Synthesis of 3-[18F]-fluoromethyl-TCP1, A potential tool for pet study of the nmda receptor channel complex

In an attempt to visualize the NMDA glutamatergic receptors and after checking the biological activity of the cold 3-fluoromethyl-TCP 3, 3-[18F]-fluoro-methyl-TCP 4 was synthesized by a nucleophilic substitution of 3-bromomethyl-TCP 5 with [18F−].