Net Meta-analysis of Efficacy Evaluation of Clearing Heat and Detoxification TCM Injections Recommended by COVID-19 in Treatment of Viral Pneumonia/ 《新型冠状病毒肺炎诊疗方案》推荐的清热解毒中药注射液治疗病毒性肺炎疗效评价的网状Meta分析

Objective: To compare the clinical efficacy of Xiyanping (XYP) Injection, Reduning (RDN) Injection and Tanreqing (TRQ) Injection in the treatment of viral pneumonia by Network Meta-analysis (NMA) Methods: Three kinds of clearing heat and detoxification traditional Chinese medicine injections in the treatment of viral pneumonia were searched in Chinese and English databases, including CNKI, Wan Fang, VIP and CBM The data in English was searched in Cochrane Library, PubMed and Embase until April 1, 2020 Results: A total of 4304 cases in 44 articles were combined into a clinical diagnosis of patients with viral pneumonia The network Meta-analysis results showed that three kinds of traditional Chinese medicine injections were better than ribavirin and the difference was statistically significant, but the ranking order difference was very weak: TRQ Injection (OR=9 1, 95%CI (4 4, 20 0), XYP Injection (OR=6 6, 95%CI (4 5,9 6), RDN Injection (OR=4 9, 95%CI (3 5, 7 3) In the comparison of antipyretic time, XYP Injection (MD=-0 99, 95%CI [-1 45, -0 56]) was better than ribavirin group (MD=-0 96, 95%CI [-1 76, -0 19]) The difference was statistically significant XYP Injection ranked better than RDN Injection In the comparison of lung rhomboid disappearance time, XYP Injection (MD=-1 59, 95%CI [-2 00, -1 20]) was better than ribavirin group (MD=-1 51, 95%CI [-2 34, -0 65]) The difference was statistically significant XYP Injection ranked better than RDN Injection In the comparison of cough disappearance time, XYP Injection was superior to ribavirin group (MD=-2 35, 95%CI [-3 07, -1 65]), and the difference was statistically significant There was no statistical difference among RDN Injection, TRQ Injection and ribavirin group In the comparison of hospital stay, the three kinds of traditional Chinese medicine injections were all better than the ribavirin group, and the difference was statistically significant RDN Injection ranked the best, followed by TRQ Injection and XYP Injection In the comparison of the incidence of adverse events, the incidence of adverse events in XYP Injection group (OR=0 36, 95%CI [0 16,0 72]), RDN Injection group(OR=0 26, 95%CI [0 13,0 50]) and TRQ Injection group (OR=0 21, 95%CI [0 041,0 73]) was lower than that in the ribavirin group, and the difference was statistically significant The incidence of adverse events in TRQ Injection was the lowest Conclusion: The effective rates of three kinds of qingrejiedu Traditional Chinese Medicine Injections were better than those of ribavirin group, but the difference in ranking order was very slight TRQ Injection had the greatest advantages in reducing the incidence of adverse events XYP Injection had the greatest advantages in three aspects, namely, the time of antipyretic fever, the time of the disappearance of lung rhomb and the time of the disappearance of cough, and RDN Injection had the greatest advantages in shortening the hospital stay