Passlve Operating On-chip PlasmaIsolation FromWholeBlood

andreagent volumes, thereby costandturn-around time Inclinical chemistry, a necessary stepperformed isthe havebeengreatly reduced. isolation ofplasma fromwholeblood, andeffective sample Inthis research, passive operating microfluidic devices, preparation techniques areneeded forthedevelopment of whichweremicromachined insilicon andglass substrate miniaturized clinical diagnostic devices. Thisstudy materials, weredemonstrated foron-chip separation of demonstrates theuseofpassive microfluidic devices, which ' operating entirely oncapillary action, foron-chip isolation of plarowhol bodThed operaeetirely upon plasma fromwholeblood. Usingthese devices, several to capillary action andmaybeusedtoeffectively isolate several tensnanoliter volumes ofplasma wereeffectively nanoliter volumes ofplasma fromasingle dropofblood separated fromasingle dropofwhole blood in2minutes. This without power-supply, movingparts, oranyexternal energy. studymay havebroadimplications inthedesign of Filtration microchannels were fabricated withdifferent lab-on-a-chip devices forbioanalytical applications. designs anddimensions. Theoperation characters were investigated andstudied.