Combination of Sonogashira coupling and 5-endo-dig cyclization for the synthesis of 2,6-disubstituted-5-azaindoles

Michael N. Balfour,Julio Zukerman-Schpector,María–José Dávila–Rodríguez,Joel S. Reis,Carlos H.A. Esteves,Hélio A. Stefani

Combination of Sonogashira coupling and 5-endo-dig cyclization for the synthesis of 2,6-disubstituted-5-azaindoles

2019

Michael N. Balfour
Julio Zukerman-Schpector
María–José Dávila–Rodríguez
Joel S. Reis
Carlos H.A. Esteves
Hélio A. Stefani

AbstractThe synthesis of a library of 2,6-disubstituted-azaindoles relying on Sonogashira cross-coupling and intramolecular cyclization is described. Eleven examples of 6-alkynyl derivatives and th...

Keywords:

Dig
Organic chemistry
Chemistry
Sonogashira coupling
intramolecular cyclization
Cascade reaction

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