Effect of local application of trypsin on postextraction alveolar osteitis.

Abstract Local application of the proteolytic enzyme trypsin (Trypure Novo) was studied for any beneficial effect on the symptoms (particularly pain) of postextraction alveolar osteitis. The trial was performed as a blind test. Of a total of seventy patients, thirty-eight selected at random were treated with trypsin and the remaining thirty-two served as controls and received a placebo. The duration of pain was not significantly shorter in the patients treated with trypsin than in those who received a placebo. Furthermore, in about 70 per cent of those who received trypsin the preparation produced a sensation of burning and in 15 per cent it caused superficial crosions at the site of application.