Genetically engineered V79 Chinese hamster cells for stable expression of xenobiotics metabolising enzymes

: V79 derived Chinese hamster cells lines with specific xenobiotica metabolising functions were constructed by gene technological means. The significance of these cell lines as a test system in toxicology and pharmacology has been demonstrated by the evaluation of metabolite profiles of pharmaceuticals and xenobiotica, and the mutagenic and cytotoxic potency of the metabolites under defined and reproducible conditions.