Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration

: In the clinic, it is a well-accepted fact that traumatic brain injury or peripheral nerve disorders affect healing of bone fractures. Recent studies have focused on the neurogenic control of bone metabolism, and the understanding of neural involvement in fracture healing and bone regeneration is increasing. In fracture healing and new bone formation, nerve fibers rapidly regenerate and increase in numbers in new bone, but decrease again during the remodeling phase. Previous studies have shown that denervation negatively affects fracture-healing. Neurotransmitters, including neuropeptides and catecholamine, are thought to play a key role in bone regeneration.