Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.

Abstract Aryl aminopyrazole amides capped with N -alkylbenzamides 13 – 16 are selective glucocorticoid receptor agonists. 2,6-Disubstituted benzamides have prednisolone-like potency or better in vitro. Good oral exposure was demonstrated in the rat, with compounds with lower lipophilicity, for example N -hydroxyethyl benzamides (e.g., 16e ).