Interaction of the serotonergic and the immune systems: 5HT-Moduline

The serotonergic system is known as a neuromodulatory system present in the brain and participating to the homeostasis of the brain. Its major morphological and anatomical features are favoring this role. Accordingly it is involved in many physiological functions and a number of psychiatric dysfunctions. Amongst the numerous receptors involved in its functions, 5HT1B receptors constitute a particular subtype located on neuron terminals and regulating the release of the corresponding neurotransmitter. These receptors are specifically the target of an endogenous tetrapeptide (5HT-Moduline) characterized in mammalian brain and regulating the functional activity of the receptor as an allosteric modulator.