Evaluation of the Platelet Mapping™ Assay on rotational thromboelastometry ROTEM®

Rotational thromboelastometry ROTEM® is available as point-of-care coagulation monitoring in an increasing number of European operating theatres and emergency rooms. The Platelet Mapping™ Assay has been described as a platelet aggregation assay for thromboelastography TEG®. The aim of this experimental trial was to evaluate feasibility of the Platelet Mapping™ Assay on the ROTEM® test system. Whole blood was drawn from 22 adult volunteers and patients with and without antiplatelet medication. Platelet aggregability was determined in three whole blood assays: the Platelet Mapping™ Assay using both activators arachidonic acid (AA) and adenosine diphosphate (ADP) on TEG®, its adapted version on ROTEM®, and the multiple electrode impedance aggregometer Multiplate®. Percent aggregation inhibition results were plotted in a linear regression analysis and correlation was estimated. Sensitivity and specificity for detecting antiplatelet medication were determined. Overall correlations were statistically significan...