Clinical research on qinglan jingao tabales for the treatment of patients with chronic obstructive pulmonary disease

Objective To explore possible preventive effect and anti-inflammatory mechanism of qinglan jingao tabales in the treatment of chronic obstructive pulmonary disease (COPD).Methods In this study,patients with acute exacerbation stage of chronic obstructive pulmonary disease (AECOPD) by qinglan jingao tabales treatment were treated as the object of study.The serum levels of TNF-α and IL-8 before and after treatment were measured by ELISA method.Meanwhile lung function measurement.To observe the changes of serum TNF-α,IL-8 and pulmonary function in patients with COPD before and after qinglan jingao tabales treatment by comparison,and to study the relationship between them.Results Patients witb AECOPD have been treated by qinglan jingao tabales,the concentration TNF-α,IL-8levels decreased significantly( P ＜0.01),MRC dyspnea score was significantly lower( P ＜0.01 ),lung function FEV1 ％ pred,FEV1 FVC,MV V.PEF improved significantly ( P ＜0.01 ).Conclusions Qinglan jingao tabales treatment significantly decreased AECOPD serum TNF-α and IL-8 levels,significantly improved dyspnea and pulmonary ventilation tunction. Key words: Chronic obstructive pulmonary disease; Tumor necrosis factor-α; Qinglan jingao tabales