Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours.
2009
Inflammatory heptocellular adenomas (IHCAs) show activation of an acute-phase inflammatory response signalling pathways, and it is found that this is due to gain-of function mutations in the IL6ST gene encoding gp130, a coreceptor for IL-6 and other cytokines that activate inflammatory signalling pathways. These mutations lead to constitutive activation of STAT3 signalling, contributing to the inflammatory phenotype of IHACs.
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