Rhodium-Catalyzed Asymmetric Cyclization/Addition Reactions of 1,6-Enynes and Oxa/Azabenzonorbornadienes

A mild, efficient, and novel rhodium catalyzed asymmetric cyclization–addition domino reaction of oxa/azabenzonorbornadienes and 1,6-enynes is documented. Through the use of a [Rh(COD)2]BF4-(R)-An-SDP catalytic system, highly enantioenriched cyclization–addition products were obtained in good yields and with excellent enantioselectivities.