α-Phosphino Amino Acids: Synthesis, Structure, and Reactivity

Abstract One-pot three-component reactions of secondary or primary phosphines and primary amines with glyoxylic acid provide a wide variety of acyclic or cyclic phosphinoglycines, in the case of some chiral amines with high diastereoselectivity. The structure, hydrolysis, oxidation, coordination at M(CO)5 (M = Cr, Mo, W), and use in nickel-catalyzed ethylene oligomerization were studied.